From the episode

The use check injury is just so big. So I like Seattle here. I think we're getting them fairly cheap. But at some point, he can only do so much, and I think the Seattle defense is that inflection point.

STACKED’s take

Negative signalInjury

McCaffrey out 2-3 weeks with left knee injury; massive blow to 49ers offense.

McCaffrey suffered a left knee injury and is expected to be out 2-3 weeks; this is described as a huge injury that significantly impacts San Francisco's offensive scheme and run game, forcing the 49ers to rely on backup Braden Willis who cannot replicate McCaffrey's role and versatility.

Christian McCaffrey headshotChristian McCaffreyRB · SFPlayer page — value, ADP, projections, and every insight