Isaac Guerendo Fantasy Football News & Podcast Insights

camp. Jordyn Tyson starts on IR-R as expected. NYG - OBJ makes thin WR room - Only five WRs streamlines projected roles - with four TEs, four RBs, and a FB kept. This clearly is now a Harbaugh operation, right down to the Old Yeller WR roster spot. NYJ - Vet QBs cut - It’s Geno Smith and an, at times, overwhelmed rookie as the only QBs on the roster with questionable coaching. What could go wrong? PHI - TE room stays crowded - Four kept tight ends, plus Grant Calcaterra set to return from IR-...

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PositiveInjuryAug 31, 2026Pat Thorman

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camp. Jordyn Tyson starts on IR-R as expected. NYG - OBJ makes thin WR room - Only five WRs streamlines projected roles - with four TEs, four RBs, and a FB kept. This clearly is now a Harbaugh operation, right down to the Old Yeller WR roster spot. NYJ - Vet QBs cut - It’s Geno Smith and an, at times, overwhelmed rookie as the only QBs on the roster with questionable coaching. What could go wrong? PHI - TE room stays crowded - Four kept tight ends, plus Grant Calcaterra set to return from IR-...

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NegativeInjuryAug 31, 2026FantasyPros Articles

Guerendo is on the mend from an injury and made the 49ers' opening day roster, but appears to be behind Kaelon Black on the depth chart as a backup to Christian McCaffrey.

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NegativeInjuryAug 31, 2026Coach Yac 🗣

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49ers RB Isaac Guerendo just posted a video on his IG of him having surgery Guerendo also had surgery back in May on his torn pec and was placed on reserve/PUP yesterday, ruling him out for the first four games of the season

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NegativeInjuryAug 31, 2026Yahoo Sports NFL

Placed on PUP (physically unable to perform) list, meaning he will not be available for the season opener against the Los Angeles Rams next Thursday in Australia.

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NegativeInjuryAug 30, 2026Niners Nation

Isaac Guerendo landed on the PUP (Physically Unable to Perform) list, removing him from the 49ers' 53-man roster and opening the running back depth chart for the season opener.

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NegativeInjuryAug 30, 2026Yahoo Sports NFL

Running back Isaac Guerendo will stay on the PUP list into the regular season, meaning he will not be available for the start of the 49ers' season.

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NegativeDepth ChartAug 30, 2026Coach Yac 🗣

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The following 49ers have been released: CB Eli Apple DL Quinton Bell S Ashtyn Davis RB Khalil Herbert WR KhaDarel Hodge WR Trenton Irwin LB Deion Jones OL Robert Jones OL Doug Kramer Jr. DL Ogbo Okoronkwo OL Brandon Parker WR Malik Turner P Corliss Waitman LS Jon Weeks The following players have been waived: OL Isaac Alarcon DL Evan Anderson TE Khalil Dinkins DL Bryson Eason DL Viliami Fehoko Jr. LB Jalen Graham WR Wesley Grimes DL Jah Joyner CB Darrell Luter Jr. QB Adrian Martinez RB Sincere...

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NegativeDepth ChartAug 30, 2026Yahoo Sports NFL

With Guerendo sidelined, the 49ers' top three running backs are Christian McCaffrey, Kaelon Black, and Jordan James. Guerendo's absence opens opportunity for backup roles to be filled by Black and James during his four-game suspension.

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NegativeInjuryAug 30, 2026Yahoo Sports NFL

Guerendo placed on reserve/PUP list due to pectoral muscle injury sustained in late May; will miss first four games of season but eligible to return to practice as early as Week 3. Missed all of training camp recovering from injury.

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NegativeInjuryAug 30, 2026Yahoo Sports NFL

Guerendo was placed on the reserve/PUP list and will miss the first four games of the season after suffering a pec injury in late May that caused him to miss all of training camp. The 49ers used the PUP designation to stash him without using an Injured Reserve spot, allowing him to return whenever ready; his 21-day practice window could open after Week 2 under the new rule.

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NegativeInjuryAug 30, 2026Niners Nation

49ers placed RB Isaac Guerendo on reserve/PUP after suffering a pec injury in late May; he will miss the first four games of the season. Guerendo missed all of training camp and was an obvious PUP candidate. Placing him on PUP allows the team to stash him without using an Injured Reserve spot, enabling his return whenever he is healthy without roster penalty.

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PositiveNewsAug 30, 2026Coach Yac 🗣

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The 49ers placed RB Isaac Guerendo (pec) on the reserve/PUP, per @JFowlerESPN

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NegativeNewsAug 30, 2026Underdog NFL

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Fowler: Isaac Guerendo (pec) placed on reserve/PUP; will miss at least 4 games.

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NegativeBustAug 28, 2026Yahoo Sports NFL

The source reports that Guerendo, a 2024 fourth-round pick, showed encouraging signs as a rookie but could soon see his time as a 49er come to an end, suggesting he may not be part of the team's long-term running back plans despite initial promise.

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NegativeDepth ChartAug 27, 2026Yahoo Sports NFL

Isaac Guerendo's roster status is uncertain; the 49ers experiment with him either ends or he lands on Injured Reserve.

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NegativeRoleAug 27, 2026Niners Nation

Isaac Guerendo's roster status is uncertain; the experiment either ends with him being waived or he lands on Injured Reserve.

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PositiveValueAug 27, 2026Legendary Upside

Isaac Guerendo is a strong comparison for a handcuff play, noted for being a valuable, low-cost target during his rookie draft cycle. He is also used as a benchmark for potential value in downside scenarios for other prospects.

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NegativeInjuryAug 26, 2026Footballguys

Guerendo has missed time with a pectoral injury, creating opportunity for Kaelon Black in the 49ers backfield.

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NegativeInjuryAug 25, 2026Yahoo Sports NFL

Running back Isaac Guerendo remains on the physically unable to perform (PUP) list.

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NegativeInjuryAug 25, 2026ESPN Fantasy Football

Guerendo is dealing with injuries in the 49ers backfield, which is entirely banged up. His health status impacts the opportunity for other backs like Kaelon Black to win the RB2 job.

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PositiveRoleAug 24, 2026Yahoo Fantasy Football - Josh & Hayden

Travis Auman identifies Isaac Guerendo as the clear RB2 for the San Francisco 49ers, highlighting his pass protection skills and ability to play faster than his athleticism. He is considered a priority waiver wire target and the preferred backup, despite potential competition from Jordan James upon his return from injury.

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NegativeDepth ChartAug 24, 2026Yahoo Sports NFL

Guerendo's health status will determine the 49ers' running back depth chart decisions, including whether Sincere McCormick remains on the practice squad.

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NegativeInjuryAug 24, 2026Niners Nation

Health status is a key variable affecting running back depth chart decisions; Sincere McCormick's practice squad spot could change depending on Guerendo's health.

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PositiveRoleAug 24, 2026Yahoo Sports NFL

Three-down running back capable of catching passes; best skill is running the ball, particularly between the tackles with zero hesitation and ability to squirt through tight creases. Displays Frank Gore-like downhill running style with speed to reach perimeter. Demonstrated toughness, staying in game after helmet-to-helmet hit from Fred Warner and exploding for 20-yard gain on subsequent carry.

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NegativeInjuryAug 23, 2026Yahoo Sports NFL

Isaac Guerendo seems likely to take a Physically Unable to Perform (PUP) designation into the regular season, ruling him out for the first four games but giving the 49ers two extra roster spots to work with.

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NegativeInjuryAug 21, 2026Yahoo Sports NFL

Isaac Guerendo, running back, is on the Active/PUP (Physically Unable to Perform) list for the San Francisco 49ers.

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NegativeInjuryAug 20, 2026Yahoo Sports NFL

Recovering from a torn pectoral muscle sustained in the offseason and currently on the Physically Unable to Perform List. If activated before the season begins, Guerendo will compete for the final running back spot against Khalil Herbert and Sincere McCormick; he has not practiced all summer due to the injury.

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NegativeInjuryAug 20, 2026Niners Nation

Guerendo is currently sidelined with a pec injury. The source notes that his roster spot is not a lock once he returns to health, creating uncertainty about his long-term role; however, the current injury situation is opening the door for him to potentially contribute when healthy.

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NegativeInjuryAug 20, 2026Yahoo Sports NFL

Isaac Guerendo is currently sidelined with a pectoral injury. Once healthy, what the 49ers do with him is uncertain as his roster spot is not a lock; however, injuries are opening the door for him to contribute.

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NegativeDepth ChartAug 18, 2026FantasyPros Articles

Isaac Guerendo has had his own injury demons to deal with during his NFL career and has seemingly fallen down the 49ers depth chart with the team drafting Jordan James and Kaelon Black in back-to-back years.

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NegativeInjuryAug 17, 2026Yahoo Sports NFL

Working on the side of the field during Sunday's practice with a pec injury; status for upcoming preseason games not explicitly stated but grouped with other sidelined backs.

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NegativeInjuryAug 17, 2026Niners Nation

Guerendo is dealing with a pec injury and was working on the side of the field during Sunday's practice; unlike James and Black, no timeline restriction was specified for his return.

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NegativeInjuryAug 17, 2026Yahoo Sports NFL

The source projects Guerendo to begin the season on the PUP list. If another injury occurs before Week 1 or if Jordan James or Kaelon Black suffer health issues, Patrick Taylor Jr. is expected to be the next man up at running back due to his special teams experience.

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Isaac Guerendo fantasy football news and podcast insights